However, calbindin promoter-dependent overexpression of the more severe ΔN131β-catenin truncation mutant results in multifocal dysplastic lesions in the small intestine after 3-4 weeks, with mice succumbing prematurely to polycystic kidney disease (Romagnolo et al., 1999). The gene discussed is CALB1; the disease is polycystic kidney disease.