Data from their study demonstrate that the highly restricted expression of endogenous Wnt5a initiates urothelium regeneration.[68] Following the infection of mice with FimH+ uropathogenic E. coli (UPEC), the virulent bacteria attached to the urothelium via FimH adhesin and triggered the rapid differentiation of basal and intermediate urothelial cells into terminally differentiated umbrella cells. The gene discussed is WNT5A; the disease is infection.