In patients with prediabetes, insulin sensitivity was lower in patients with a BMI ≥ 22.3 kg/m2 than in patients below this cut-off (Matsuda ISI 10.17 ± 6.02 vs. 14.74 ± 6.25, p = 0.11 after adjustment for gender and age). This evidence concerns the gene INS and prediabetes syndrome.