TTK and neoplasm: Both molecules potently inhibit Mps1 in MDA-MB-468 tumor cells as monitored by modulation of the proximal biomarker pHH3-Ser10 (PF-7006 IC50 = 2.5 ± 1.0 nM, n = 5; PF-3837 IC50 = 5.5 ± 2.1 nM, n = 10).