In order to evaluate the relationship between circulating ANGPTL2 level and HF, the circulating ANGPTL2 levels were divided into tertiles (ANGPTL2 level ≤3.4 ng/mL, n = 100; 3.4 ng/mL< ANGPTL2 level ≤ 4.8 ng/mL, n = 100; ANGPTL2 level >4.8 ng/mL, n = 100) and analyzed as categorical variables. This evidence concerns the gene ANGPTL2 and hydrops fetalis.