PSIP1 and antiphospholipid syndrome: Given the large number of patients included and the large number of patients described here, we can assume that the presence of anti-DFS70 antibodies (at titers >1:160) may constitute an immune-mediated prothrombotic state at high risk for thrombotic adverse complications as observed in antiphospholipid syndrome or in heparin induced thrombocytopenia [33–35].