CBFB and acute myeloid leukemia: RUNX1 has shown to play a crucial role in haematopoiesis during embryonic development [18] and the two subunits of the core binding factors (CBFs), i.e., CBFA and CBFB, have been suggested to modify the transcriptional regulator functions of AML by either altering the normal RUNX1 transcription program, interfering with the RUNX1 assembly, or recruiting histone deacetylases and inhibiting the RUNX1 activity [19–21].