CEBPZ and acute myeloid leukemia: Of the total of 1567 genes that are differentially expressed in all CBF AML cases [1291 in t(8;21) and 474 in Inv(16)], compared to samples with normal karyotype (NK), 198 differentially expressed genes are shared by the two subtypes in CBF AML (Fig 3A): 87 of these genes are up-regulated, 88 are down-regulated in both subtypes (S4 Table), while another 23 genes have opposing expression profiles (down-regulated in one subtype but up-regulated in the other).