Several immunoglobulin-related gene families, including the Leukocyte Immunoglobulin-like Receptor (LIR) gene family and the Immunoglobulin Heavy (IGH) gene family, were also enriched in down-regulated genes for the t(8;21) AML samples, while no molecular processes or functions were enriched in up-regulated genes for the t(8;21) AML samples. This evidence concerns the gene CD300C and acute myeloid leukemia.