Moreover, CRC-113 gene signature significantly exhibited further hierarchical discrimination in the status of DNA alterations: MMR proficient (pMMR, p = 6.34e-04) and MMR deficient (dMMR, p = 0.05) (Supplementary Figure S5B and S5C); CIN-high (p = 5.24e-03) and CIMP-low (p = 0.032) (Supplementary Figure S5F and S5H), KRAS WT (p = 1.32e-03, Supplementary Figure S6B), p53 M (p = 1.05e-03, Supplementary Figure S6F), and BRAF WT (p = 0.024, Supplementary Figure S6H). Here, TP53 is linked to colorectal carcinoma.