CCN2 and cancer: Also, CRC-113 gene signature includes a number of hypoxia and inflammation-related genes in various cancer such as AKAP12 [63], ANXA1 [64, 65], CCL11 [66], CTGF [67], FABP4 [68], FN1 [69], IGFBP3 [70], LOX [71], NOX4 [72, 73], NRP1 [74], OLR1 [75], SLC2A3 [76] and WNT5A [77], indicating that hypoxia and inflammation, which are two inseparable hallmarks in tumorigenesis [78], really play important roles in CRC pathogenesis.