In association analysis using χ2 test, the CRC-113 gene signature risk was remarkably interrelated with each DNA alteration: MMR (p = 1.33e-05, Figure 4A), CIN (p = 0.035, Figure 4B), CIMP (p = 0.045, Figure 4C), KRAS (p = 1.91e-03, Figure 4D) and p53 status (p = 3.88e-04, Figure 4E), except for BRAF status (p = 0.053, Figure 4F). The gene discussed is TP53; the disease is colorectal carcinoma.