While most of the demonstrated effects of triptolide action have been the inhibition of HSP70 function or transcriptional inhibition of several tumor promoting genes, our studies highlight yet another aspect of its mechanism of action viz., HSP90 inhibition as evidenced by reduced in vivo BTK-PLCγ2-AKT signaling [11, 30, 52]. This evidence concerns the gene PLCG2 and neoplasm.