The result of fixed effect model (p < 0.0001, HR = 1.83, 95%CI: 1.38-2.45) and random effect model (p = 0.0008, HR = 1.87, 95% CI: 1.30-2.71) of meta-analysis all indicated a significant prognostic impact of the E2F7 expression in a total of 696 tamoxifen-treated breast cancer patients (Figure 5D). Here, E2F7 is linked to breast cancer.