PBRM1 and hereditary clear cell renal cell carcinoma: For example, mutations of PB1 are frequently found in renal cell carcinoma and expression levels of PB1 are a prognostic marker for metastatic renal cell carcinoma [51,52] and the SWI/SNF subunit BRG1 has been shown to be required for maintenance of acute myeloid leukemia [53].