Thus, the increased calretinin expression in mesothelioma cells and moreover in certain colon cancer (83) and derived cell lines (84) might be correlated or causally linked to the increased resistance of these tumor cells to the apoptotic/necrotic signals either occurring in healthy physiological conditions or resulting from treatment with chemotherapy drugs such as oxaliplatin or 5-fluorouracil (85). The gene discussed is CALB2; the disease is colonic neoplasm.