Rs4679868 A and rs9852519T alleles (both in IL-12A) have been associated with increased risk of primary biliary cirrhosis [30] whereas the A allele of rs6131 (SELP) has been found to lower platelet activation upon release of the cross-clamp in patients undergoing coronary artery bypass graft [31]. The gene discussed is SELP; the disease is primary biliary cholangitis.