However, after DKK3 transfection, consistent with the results reported by Xiang, we also found that DKK3 inhibits the nuclear accumulation and the activation of β‐catenin and its downstream genes cyclin D1, c‐Myc in pancreatic cancer Bxpc‐3 cell in normoxia and hypoxia. Here, DKK3 is linked to familial pancreatic carcinoma.