In conclusion, these experiments demonstrated that DKK3 suppresses EMT of pancreatic cancer Bxpc‐3 cell in hypoxic conditions by blocking the translocation of β‐catenin to nucleus, leading to the enhancing of the antitumour effects of gemcitabine in pancreatic cancer Bxpc‐3 cell. The gene discussed is DKK3; the disease is pancreatic neoplasm.