To further recognize the regulation potential of seaweed polyphenols in the stem cell-related transcriptional machinery that drives EMT, pluripotency maintenance, and the self-renewal capacity of PC-CSCs, we examined the transcriptional modulations of EIF4C, OCT3/4, Nanog, LIF, and ZIC3 in PC-CSCs. The gene discussed is LIF; the disease is pachyonychia congenita.