SEMA5A and neurodevelopmental disorder: Indeed, a combination of rare inherited variants was reported in a subset of patients, suggesting a ‘multiple hit' model of ASD.36, 37 Altogether, the role of SEMA5A variants in ASD seems limited and very large-scale studies are warranted to associate this gene to ASD, but given the importance of semaphorins in the wiring of the brain, any information on the clinical consequences of deleterious variants affecting this family of proteins remains very helpful to understand the numerous neurobiological mechanisms leading to neurodevelopmental disorders.