In this study, apart from detecting mutations in genes previously associated with HNSCC (TP53, NOTCH1, FAT1, and CASP8), they also identified recurring alterations in genes specific to this disease (USP9X, MLL4/KMT2B, ARID2, UNC13C, and TRPM3) [22]. This evidence concerns the gene CASP8 and head and neck squamous cell carcinoma.