For example, compared to Wt B6 mice, gld and lpr mice are highly resistant to the development of experimental autoimmune encephalomyelitis (EAE) [43–45] and EAU [46], which share essential cellular mechanisms, indicating involvement of Fas/FasL in the T cell-mediated tissue inflammation. The gene discussed is FASLG; the disease is experimental autoimmune encephalomyelitis.