FAP and neoplasm: In spite of the highly significant suppressive effects of irradiated non-transfected tumor cells from tumor growth in the CT26 colon carcinoma model, the pFAP-transfected tumor cells exhibited enhanced inhibitory effects on tumor onset and growth in multiple tumor models, implying that the FAP-expressing tumor cells could elicit strong protective and therapeutic anti-tumor immunity and enhance the efficacy of immunotherapy based on whole-tumor cell vaccines.