TP53 and cancer: BTG2 mRNA induction (up to 10-fold) on SETD1A depletion was observed in multiple breast (n=4), prostate (n=2), lung (n=2) and colon (n=6) cancer cell lines, and it was independent of the mutational status of p53, a known regulator of BTG2 (Fig. 1c and Supplementary Fig. 2b; P<0.05, Student's t-test).