Additional computational analyses (Gene, Disease Features Ontology-based Overview System) showed that 21 of the 31 genes common between MDA-MB-231 and A549 cells (targeted by 24 SETD1A-induced miRNAs) were significantly related to the p53 pathway, neoplasms and cell cycle regulation (Supplementary Fig. 7a); StarBase enrichment analysis21, 22 of these 24 SETD1A-induced miRNAs shows that they are significantly enriched for components associated with negative regulation of cell proliferation, and p53 and cancer-associated pathways (Supplementary Fig. 7b). This evidence concerns the gene TP53 and cancer.