NOTCH1 and neoplasm: Similarly, a family of membrane bound receptors related to the protein NOTCH (NOTCH1, NOTCH2, NOTCH3 and NOTCH4) interact with membrane bound ligands (JAGGED-1 or JAG1, JAG2, delta-like-1 or DLL1, DLL3 and DLL4) and act to regulate cell proliferation, differentiation and apoptosis, as well as angiogenesis and tumor cell migration [5, 6].