We showed that the LV-NR-R80Q-apoB reduced the accumulation of α-syn and the propagation of α-syn from oligodendrocytes to astroglia, ameliorated the neurodegenerative pathology including myelination and reversed the behavioral deficits in the MBP-α-syn tg mouse model of MSA. The gene discussed is MBP; the disease is multiple system atrophy.