Notably, VEGF and EPO are HIF-1α targets involved in angiogenesis and oxygen supply to cells, while SOX2 is a transcriptional target of HIF-2α and is a stemness target implicated in the undifferentiated nature of the mesenchymal component predominant in hemangioblastomas [17-19]. This evidence concerns the gene EPAS1 and hemangioblastoma.