Intriguingly, in contrast to Drosophila or cancer cells, where c-Myc has been reported to be positively regulated by Yap (Neto-Silva et al., 2010; Stocker, 2011; Xiao et al., 2013), we found that its expression is enhanced in the CMZ of Yap morphant tadpoles. The gene discussed is MYC; the disease is cancer.