Three genes belong to five of these gene sets: the monocyte chemokines CXCL10 and CXCL11, and the pro-inflammatory cytokine IL6. The two interferon-signaling pathways share a block of genes that function in the innate immune response to viral infection, which includes the DEG OASL as well as IRF7, STAT2, DDX58, ISG15, USP18, and MX1. Inflammatory response genes include the pro-inflammatory cytokines CCL2, IL1B, IL6, and IL8, Pattern Recognition Receptors TLR1, TLR2, TLR3, and CLEC5A, and intracellular signaling molecules NFKBIA, IRAK2, RIPK2, and RASGRP1. This evidence concerns the gene ISG15 and viral infectious disease.