In this study we show that the acceleration of AngII-induced hypertension by OT corroborated the significant renal damage characterised by tubular epithelial cell necrosis and desquamation, vacuolisation and degeneration of basement membranes, luminal congestion with loss of brush borders, enlargement of Bowman's cavities and, interstitial fibrosis. Here, AGT is linked to hypertensive disorder.