NTN1 and cancer: Our data revealed that Colo-357 shMUC4 and Capan-1 shMUC4 cells transfected with the pGL3-NTN1 WT plasmid showed lower activities than the corresponding Scr-treated cells, whereas this difference was not observed when cancer cells were transfected with pGL3-NTN1 mutant construct (Figure 7F and 7G).