In contrast, differences of TL1A concentrations across CLL prognostic classes defined by Binet clinical staging, IGHV status, ZAP-70 expression, or cytogenetics were not statistically significant, although TL1A levels were tendentiously higher in patients at a Binet A stage, with mutated IGHV, ZAP-70 negative, or neutral/favorable cytogenetics. This evidence concerns the gene ZAP70 and B-cell chronic lymphocytic leukemia.