Although E2F1 has been shown to be a cell cycle progressor in many cellular contexts, studies show that in murine CD8+ T cells, E2F1 and E2F2 redundantly restrict cell cycle progression and proliferation following sub-threshold antigen stimulation, and mice are more prone to autoimmunity [52,53,54,55,56,57,58,59,60]. The gene discussed is E2F1; the disease is Autoimmunity.