To identify transcriptional pathways that may underlie hypofunctional TILN relative to functional tumor-specific CD8+ T cells in circulation, we next applied Ingenuity Pathway Analysis (IPA) to the list of differentially-expressed genes and corresponding fold-changes previously published by the original authors (Figure 2, Figure 3, Figure 4 and Figure 5 and Table 2) [35,145]. This evidence concerns the gene CD8A and neoplasm.