IFNL2 and infection: In that regard, studies in neonatal IPS-1 deficient mice (C57BL/6 background) have shown that the absence of IPS-1 led to an increased viral load and decreased production of IFN-β and IFN-λ2/3 at day 1 after hMPV infection [58], indicating that IPS-1 contributes to the antiviral response and hMPV clearance.