Significant advancements have also been achieved in the area of melanoma immunotherapy, with the development of drugs such as Ipilimumab (Human IgG1 antibody against CTLA-4) and Nivolumab (antibody against PD-1), but in the current review, the focus will be on BRAF-targeted therapies and the associated acquired resistance. The gene discussed is BRAF; the disease is melanoma.