Because the expression of β-catenin has been demonstrated to sensitize BRAFi-resistant melanoma cells [107], and WNT5A signaling can negatively regulate WNT/β-catenin signaling in the BRAFi-resistant melanoma cells [101] one can forward a notion that Box-5 might indirectly affect the β-catenin expression levels thereby making BRAFi-resistant melanomas more sensitive towards BRAFi. This evidence concerns the gene WNT5A and melanoma.