Studies in a variety of experimental systems now point towards a consensus on the presence HH in neoplastic colorectal epithelium: Oniscu et al. [7] reported expression of SHH, PTCH and SMOH in hyperplastic colorectal polyps, adenomas and carcinoma, and also showed increased cell growth in primary mouse colonocytes treated with SHH peptide. Here, SHH is linked to carcinoma.