CXCL8 and metabolic syndrome: For example, a three month intervention study reported that a very low-carbohydrate diet (12% of energy from carbohydrates daily) resulted in more reduction in IL-6, IL-8, and TNF-alpha concentrations than did in a low-fat diet (25% fat, with 10% saturated fat) in 40 young adults with dyslipidemias [29].