The authors then genotyped the five single nucleotide polymorphisms (SNPs) (rs12255372, rs7903146, rs7901695, rs11196205, and rs7895340) within a well-defined linkage disequilibrium (LD) block of 92.1 kb spanning intron 3 and intron 4 of TCF7L2 and showed association between all five SNPs and T2DM in all three cohorts. This evidence concerns the gene TCF7L2 and type 2 diabetes mellitus.