TNFRSF8 and Hodgkins lymphoma: A phase 1 dose-escalation study investigating the safety and activity of BV in 45 heavily pretreated patients with CD30 positive hematologic malignancies (42 with HL) showed that the agent had promising activity with objective responses seen in 17 patients (11 CR) with moderate adverse events, the most clinically significant being peripheral neuropathy, seen in 22% of patients [31].