CP-101,606 (traxoprodil), a selective GluN2B antagonist, has been demonstrated to produce an antidepressant effect at a dose with a low potential for producing dissociative effects in patients with TRD (30 patients) after a single intravenous infusion; furthermore, 78% of CP-101,606-treated patients maintained their response status for one week, and 32% maintained their response status for 30 days after the infusion [9]. The gene discussed is GRIN2B; the disease is treatment resistant depression.