In contrast, HMGB1 could be inhibited by PPARγ agonists [50]; (2) HMGB1 activated RAGE/NF-кB [63,69] and/or TLR-4/caspase-1 [36] for HCC metastasis; (3) HMGB1 also mediated the activation of metastasis by inducing IL6/Stat3-miR-21 axis [67]. This evidence concerns the gene HMGB1 and hepatocellular carcinoma.