STC1 and glioblastoma: Interestingly, administration of anti-GBM Ab following kidney-specific knockdown of STC1 resulted in: severe proximal tubular epithelial injury and sloughing, as determined by loss of AQP1 staining (Fig 2); massive cast formation and severe tubular dilation; 7-fold greater number of glomeruli with necrosis/hyalinosis; and greater expansion of the tubulointerstitial compartment (Fig 2 and Table 1).