CNTF and Stroke: CNTF is a neurotrophic factor produced by astrocytes, which supports the proliferation88 and survival89, 90, 91 of oligodendrocyte precursors and regulates myelination.74 Studies have shown that CNTF can mediate stroke-induced adult central nervous system neurogenesis92 and that CNTF injection can increase remyelination in cuprizone-induced multiple sclerosis mice,93 supporting the role of CNTF as a neurotrophic factor and as a myelin regulator.