Cldn11 codes for Claudin-11, which is a major component of myelin and forms tight junctions within myelin sheaths.100 Downregulation of Cldn11 has been found in bipolar affective disorder patients.101 Also Plp1 and Cnp showed a negative correlation with anxiety-like behavior (OFC) in the OFT. The gene discussed is PLP1; the disease is Anxiety.