Consistent with this, tumor cells that retain R2/B in the truncated APC have low levels of phospho-βcat (Yang et al., 2006), suggesting APC is still able to facilitate βcat transfer out of the destruction complex due to the presence of the Arm rpts, R2 and B (although the transfer would be less efficient due to loss of the SAMPs, the Axin binding sites). Here, APC is linked to neoplasm.