Polyak et al, using a similar mouse model (Cx3cr1 gfp/gfp compared to Cx3cr1 +/gfp), but feeding a fat-enriched diet (2:1 mixture of chow and lard) for only 10 weeks, reported that the Cx3cr1 null mice had decreased weight gain and lesser visceral white adipose tissue as well as protection from glucose intolerance and adipose inflammation[26]. This evidence concerns the gene CX3CR1 and Glucose intolerance.