CX3CR1 and Insulin resistance: In Morris et al’s studies of a fractalkine deficient model (Cx3cr1 gfp/gfp compared to heterozygote Cx3cr1 +/gfp) fed a 60% high fat diet for 20 weeks, Cx3cr1-/- did not attenuate adipose inflammation or the development of peripheral insulin resistance, assessed by intraperitoneal glucose tolerance test and insulin tolerance test at 20 weeks.