In Morris et al’s studies of a fractalkine deficient model (Cx3cr1 gfp/gfp compared to heterozygote Cx3cr1 +/gfp) fed a 60% high fat diet for 20 weeks, Cx3cr1-/- did not attenuate adipose inflammation or the development of peripheral insulin resistance, assessed by intraperitoneal glucose tolerance test and insulin tolerance test at 20 weeks. Here, CX3CL1 is linked to Insulin resistance.