We found that miR-200c levels were inversely correlated with clinical stage, local relapse and distant metastasis (P = 0.017, 0.019 and 0.033 respectively) (Table 1) but not correlated with age, menopause, tumor size, lymph node metastasis, ER, PR, HER2 and P53 status among the 134 breast cancer patients. This evidence concerns the gene ESR1 and breast carcinoma.