AKT1 and leukemia: In addition to major cytogenetic alterations, genomic or expression profiling has recently identified the activation of several signal transduction pathways, including phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR), Ras/Raf/MEK/Erk, Jak/STAT and others as driving features of leukemia [32–34].