Because isotype control antibodies and a control tribody had no effects, both B7-H6:HER2-scFv and AICL:HER2-scFv required interaction with the target antigen HER2 and engagement of the corresponding trigger molecule (i.e. NKp30 and NKp80, respectively) to induce NK cell-mediated tumor cell lysis. This evidence concerns the gene NCR3 and neoplasm.