Finally, using a publicly available data site (R2: microarray analysis and visualization platform [40]; Tumor breast EXPO-351) with gene expression profiles of 351 primary breast cancers, we found positive correlation between expression of TLR4 mRNA and IL-6 (r value 0.231, P = 1.3e-05) (Fig. 6c). This evidence concerns the gene TLR4 and breast cancer.