While not formally statistically significant after adjustment for multiple testing, the associations between HL risk and ROH, as demonstrated by ROH111 (which harbours NF-κB1), and ROH375 (previously implicated in susceptibility to childhood B-cell precursor acute lymphoblastic leukaemia [BCP-ALL])43, may reflect regions that warrant further investigation. This evidence concerns the gene NFKB1 and acute lymphoblastic leukemia.