BRCA1 and ovarian carcinoma: While these functional studies were ongoing, a meta-analysis of the OCAC genetic association results with the results of an equivalent analysis of modifiers of ovarian cancer risk in 15,252 BRCA1 mutation carriers and 8,211 BRCA2 mutation carriers was conducted by the Consortium of Investigators of Modifiers of BRCA1/2 (ref. 19).