APLN and Stroke: There were significantly more BrdU+/collagen IV+ colabeled cells in the peri-infarct region in apelin-13-treated stroke animals (45.2 ± 6.7 vs. 74.5 ± 6.7 in stroke + vehicle and stroke + apelin-13 groups, respectively; p < .05, n = 6 animals each group), suggesting enhanced angiogenesis in apelin-13-treated animals (Figure 4(a) and (b)).