In preliminary analyses, basal phosphorylation and expression of ERK and AKT were unaltered by the overexpression or silencing of SOCS1 in CT26 and CT36 CRC cells (data not shown), suggesting that activation of these oncogenic pathways is not underlying the pro-oncogenic effect of SOCS1 in CRC cells. This evidence concerns the gene SOCS1 and colorectal carcinoma.