Besides, when compared to normal tissues, SOCS1 expression was found up-regulated in stage I and II colon adenocarcinomas (P = 0.0081 and P = 0.002, respectively, Mann Whitney test), and to a lesser extent in stage III (P = 0.0398), but not in stage IV tumours (Fig. 1D). Here, SOCS1 is linked to colon adenocarcinoma.