SOCS1 and neoplasm: Analysis of SOCS1 relative gene expression in all 431 human CRC patients from the TCGA gene expression datasets showed a significant increase of SOCS1 mRNA in tumour specimens compared to non-tumour colon tissues [Median SOCS1 RSEM normalized expression28 of 65.29 in normal tissues vs. 107.3 in tumours, Mann Whitney test, P = 0.0105].