Osteocytes are key regulators of bone modeling and remodeling [5] and current data suggest that CKD is associated with abnormal expression of different osteocytic proteins [6,7], some of which, such as fibroblast growth factor 23 (FGF23) and dentin matrix protein 1 (DMP1), play a role in regulating skeletal mineralization and others of which (namely sclerostin) regulate osteoblast differentiation [5,8]. This evidence concerns the gene FGF23 and chronic kidney disease.